Rzadko się o tym pisze, a przecież trzeba wiedzieć, że twór o nazwie „fosfatydylseryna” jest fosfolipidem niezbędnym dla życia i funkcjonowania komórek mózgowych, które sterują całym organizmem, nie wyłączając układu mięśniowego.
Co to takiego – fosfolipidy?
Otóż są to molekuły zawierające aminokwasy i kwasy tłuszczowe będące składnikami każdej błony komórkowej organizmu. W ich skład wchodzą kwasy tłuszczowe, gliceryna i kwas fosforowy.
We wszystkich schorzeniach wątroby obserwuje się ubytek fosfolipidów w błonach komórkowych, a przecież pełnią one funkcję nie do przecenienia:
-Hamują proces włóknienia w wątrobie
-Stymulują rozpuszczalność cholesterolu w żółci
-Poprawiają proces trawienia tłuszczów
-Są niezbędne do wchłaniania się witamin A,E,D,K
-Działają przeciwmiażdżycowo
-Poprawiają transport cholesterolu z innych tkanek do wątroby
-Udoskonalają przepływ krwi w naczyniach, zwiększając elastyczność krwinek.
Fosfatydyloseryna a kortyzol:
The effects of phosphatidylserine on endocrine response to moderate intensity exercise
Background
Previous research has indicated that phosphatidylserine (PS) supplementation has the potential to attenuate the serum cortisol response to acute exercise stress. Equivocal findings suggest that this effect might be dose dependent. This study aimed to examine the influence of short-term supplementation with a moderate dose of PS (600 mg per day) on plasma concentrations of cortisol, lactate, growth hormone and testosterone before, during, and following moderate intensity exercise in healthy males.
Methods
10 healthy male subjects participated in the study. Each subject was assigned to ingest 600 mg PS or placebo per day for 10 days using a double-blind, placebo-controlled, crossover design. Serial venous blood samples were taken at rest, after a 15 minute moderate intensity exercise protocol on a cycle ergometer that consisted of five 3-minute incremental stages beginning at 65% and ending at 85% VO2 max, and during a 65 minute passive recovery. Plasma samples were assessed for cortisol, growth hormone, testosterone, lactate and testosterone to cortisol ratio for treatment (PS or placebo).
Results
Mean peak cortisol concentrations and area under the curve (AUC) were lower following PS (39 ± 1% and 35 ± 0%, respectively) when compared to placebo (p < 0.05). PS increased AUC for testosterone to cortisol ratio (184 ± 5%) when compared to placebo (p < 0.05). PS and placebo supplementation had no effect on lactate or growth hormone levels.
Conclusion
The findings suggest that PS is an effective supplement for combating exercise-induced stress and preventing the physiological deterioration that can accompany too much exercise. PS supplementation promotes a desired hormonal status for athletes by blunting increases in cortisol levels.
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Dwie grupy
-placebo
-grupa spozywajaca 600mg PS (fosfatydyloseryny)
Wnioski:
po 10dniowym okresie zanotowana nastepujące zmiany
-u grupy przyjmującej PS 600mg odnotowano mniejszy poziom kortyzolu, ale rownież większy poziom testosteronu
Zanotowano zmniejszenie poziomu kortyzolu o 35%
testosteron o 37%
ratio tesosteron/kortyzol o 184%
The effect of phosphatidylserine on golf performance
Background
A randomized, double-blind, placebo-controlled study was performed to evaluate the effect of oral phosphatidylserine (PS) supplementation on golf performance in healthy young golfers with handicaps of 15-40.
Methods
Perceived stress, heart rate and the quality of the ball flight was evaluated before (pre-test) and after (post-test) 42 days of 200 mg per day PS (n = 10) or placebo (n = 10) intake in the form of a nutritional bar. Subjects teed-off 20 times aiming at a green 135 meters from the tee area.
Results
PS supplementation significantly increased (p < 0.05) the number of good ball flights (mean: pre-test 8.3 ± 3.5, post-test 10.1 ± 3.0), whereas placebo intake (mean: pre-test 7.8 ± 2.4, post-test 7.9 ± 3.6) had no effect. PS supplementation showed a trend towards improving perceived stress levels during teeing-off (mean: pre-test 5.8 ± 2.0, post-test 4.0 ± 2.0, p = 0.07), whereas stress levels remained unchanged in the placebo group (mean: pre-test: 5.1 ± 2.0, post-test: 5.1 ± 3.1). Supplementation did not influence mean heart rate in either group.
Conclusion
It is concluded that six weeks of PS supplementation shows a statistically not significant tendency (p = 0.07) to improve perceived stress levels in golfers and significantly improves (p < 0.05) the number of good ball flights during tee-off which might result in improved golf scores.
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Dwie grupy
-placebo
-grupa przyjmujaca PS w dawce 200mg
Po 42 dniach odnotowano lepszą skuteczność u golfiarzy o 20% jezeli chodzi o ilość celnych trafien
jak rownież spadek poziomu koryzolu o 32%
Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men.
The effect of chronic administration of phosphatidylserine derived from brain cortex on the neuroendocrine responses to physical stress has been examined in a placebo-controlled study in 9 healthy men. Phosphatidylserine 800 mg/d for 10 days significantly blunted the ACTH and cortisol responses to physical exercise (P = 0.003 and P = 0.03, respectively), without affecting the rise in plasma GH and PRL. Physical exercise significantly increased the plasma lactate concentration both after placebo and phosphatidylserine. The results suggest that chronic oral administration of phosphatidylserine may counteract stress-induced activation of the hypothalamo-pituitary-adrenal axis in man.
800 mg BC-PS supplementation lowered cortisol response by 30%, whereas 400 mg showed no significant results compared to placebo
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suplementacja 800mg PS skutkowala obnizeniem poziomu kortyzolu o 30% w porownaniu do grupy placebo
Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress.
Phosphatidylserine, derived from cow brains, has been shown previously to dampen the ACTH and cortisol response to physical stress. Further research investigated the influence of soy lecithin phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. In this study, we investigated the effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) supplementation on pituitary adrenal reactivity (ACTH, cortisol) and on the psychological response (Spielberger State Anxiety Inventory stress subscale) to a mental and emotional stressor. Four groups of 20 subjects were treated for three weeks with daily dosages of either 400 mg PAS, 600 mg PAS, 800 mg PAS, or placebo before exposure to the Trier Social Stress Test (TSST). Treatment with 400 mg PAS resulted in a pronounced blunting of both serum ACTH and cortisol, and salivary cortisol responses to the TSST, but did not affect heart rate. The effect was not seen with larger doses of PAS. With regard to the psychological response, 400 mg PAS seemed to exert a specific positive effect on emotional responses to the TSST. While the placebo group showed the expected increase in distress after the test, the group treated with 400 mg PAS showed decreased distress. These data provide initial evidence for a selective stress dampening effect of PAS on the pituitary-adrenal axis, suggesting the potential of PAS in the treatment of stress related disorders.
Opracował: Grammatikk
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